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LIPODEX B columns

Capillary columns for GC enantiomer separation. LIPODEX cyclodextrin phases are made of cyclic oligosaccharides consisting of six (a-cyclodextrin), seven (ß-cyclodextrin) or eight (?-cyclodextrin) glucose units bonded through a-1,4-linkages. Regioselective alkylation and/or acylation of the hydroxyl groups leads to lipophilic phases with varying enantioselectivity, which are well suited for chiral analyses. Important advantage - many compounds can be analyzed without derivatization (however, for certain substances enantioselectivity can be favorably influenced by formation of derivatives). A large number of separations have been achieved, however, it is not possible to make a general prediction, which phase could solve a given separation task. Even for compounds with small structural differences or within homologous series the enantiodifferentiation can be quite different.